New GU Service Line at MLabs


To facilitate clinical translation of emerging molecular advances in an efficient, accurate and expeditious manner, a “service line” concept was conceived by Jeffrey L. Myers, M.D., and Jay L. Hess, M.D., Ph.D., at University of Michigan Health System (UMHS) where content subspecialists (i.e., diagnostic pathologists, molecular biologists, cytogeneticists, medical oncologists, etc.) work closely to advance molecular diagnostics in areas of clinical need. A diverse array of specialists and personnel within the Department of Pathology at UMHS, including the Clinical Cytogenetics Laboratory and Michigan Center for Translational Pathology (MCTP), has contributed significantly to make this concept a practical reality.

MCTP faculty member Dr. Rohit Mehra serves as the Director of MLabs’ GU Service Line, he is also Co-Director of the recently re-energized Rapid Autopsy Discovery Program. The genitourinary service line laboratory currently offers fluorescent in situ hybridization (FISH) assays for TFE3 and TFEB gene aberrations and is actively working on new assays for inclusion in its clinical menu. Other assays on offer at UMHS include: locus control probes to confirm trisomy 7 and 17 in patients with papillary renal cell carcinoma; break-apart FISH probes to detect ERG, ETV1, BRAF and RAF1 fusions in prostate cancer; and locus control probes to detect loss of PTEN in prostate cancer.